Cancers in adults under 50 are rising ‘dramatically,’ say researchers from Brigham and Women’s Hospital

EARLY CANCER, THAT ARE DIAGNOSED BEFORE AGE, ARE ALWAYS COMMON WITH EACH GENERATION. THAT FOLLOWS NEW INVESTIGATION FROM BRIGHAM AND THE WOMEN’S HOSPITAL. SOMEONE BORN IN 1960 LIVES A HIGHER RISK OF BEING BORN BEFORE AGE THAN SOMEONE BORN IN 1950. THE HOSPITAL HOPES TO COOPERATE WITH INTERNATIONAL RESEARCH GROUPS

Cancers in adults under 50 are rising ‘dramatically,’ say researchers from Brigham and Women’s Hospital

According to researchers at Brigham and Women’s Hospital in Boston, the incidence of early-onset cancers diagnosed before age 50, including cancers of the breast, colon, esophagus, kidneys, liver, and pancreas, is “increased dramatically” in recent decades. The scientists conducted extensive analyzes of data available in the literature and online, including information on early life exposures, that may have contributed to the trend in an effort to understand why more young people are being diagnosed with cancer. “From our data, we observed something called the birth cohort effect. This effect shows that each successive group of people born at a later date (e.g. ten years later) has a higher risk of developing cancer later in life , probably from risk factors they were exposed to at a young age,” said Shuji Ogino. , MD, Ph.D., a professor and physician-scientist in the Brigham’s Department of Pathology. “We found that this risk increases with each generation. For example, people born in 1960 had a higher risk of cancer before they turned 50 than people born in 1950, and we predict that this level of risk will continue to rise in successive generations. lifestyle may contribute to the early cancer epidemic, the team recognized that the increased incidence of certain cancer types is partly due to early detection through cancer screening programs. Possible risk factors for early-stage cancer included alcohol consumption, sleep deprivation, smoking, obesity and eating highly processed foods. Scientists said one limitation of the study is that researchers did not have enough data from low- and middle-income countries to identify trends in cancer incidence over the decades. In the future, they hope to continue this research by collecting more data and collaborating with international research institutes to better track global trends. The results of the study have been published in Nature Reviews Clinical Oncology.

According to researchers at Brigham and Women’s Hospital in Boston, the incidence of early-onset cancers diagnosed before age 50, including cancers of the breast, colon, esophagus, kidneys, liver, and pancreas, is “increased dramatically” in recent decades. .

The scientists conducted extensive analyzes of data available in the literature and online, including information on early life exposures, that may have contributed to the trend in an effort to understand why more young people are being diagnosed with cancer.

“From our data, we observed something called the birth cohort effect. This effect shows that each successive group of people born at a later date (e.g. ten years later) has a higher risk of developing cancer later in life , probably from risk factors they were exposed to at a young age,” said Shuji Ogino. , MD, Ph.D., a professor and physician-scientist in the Brigham’s Department of Pathology. “We found that this risk increases with each generation. For example, people born in 1960 had a higher risk of cancer before turning 50 than people born in 1950, and we predict that this level of risk will continue to rise in successive generations.”

Researchers said that people’s diet, lifestyle, weight and exposure to the environment have changed significantly in recent decades. Therefore, they hypothesized that factors such as westernized diet and lifestyle may contribute to the early cancer epidemic.

The team acknowledged that the increased incidence of certain cancers is due in part to early detection through cancer screening programs.

Possible risk factors for early-stage cancer included alcohol consumption, sleep deprivation, smoking, obesity and eating highly processed foods.

Scientists said one limitation of the study is that researchers did not have enough data from low- and middle-income countries to identify trends in cancer incidence over the decades.

In the future, they said they hope to continue this research by collecting more data and collaborating with international research institutes to better track global trends.

Results of the study published in Nature Reviews Clinical Oncology.

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