COVID-19 shoots are unlikely to cause infrequent inflammation in children
COVID-19 shoots are unlikely to cause infrequent inflammation in children

COVID-19 shoots are unlikely to cause infrequent inflammation in children

COVID-19 vaccines are unlikely to trigger a rare inflammatory condition associated with coronavirus infection in children, according to an analysis of U.S. government data released Tuesday.

The condition, formally known as multisystem inflammatory syndrome in children, involves fever plus symptoms that affect at least two organs and often include abdominal pain, skin rash or bloodshot eyes. It is a rare complication in children who have had COVID-19 and who very rarely affect adults. The condition often leads to hospitalization, but most patients recover.

First reported in the United Kingdom in early 2020, it is sometimes confused with Kawasaki disease, which can cause swelling and heart problems. Since February 2020, more than 6,800 cases have been reported in the United States, according to the Centers for Disease Control and Prevention.

As part of the COVID-19 vaccine safety monitoring, the CDC and US Food and Drug Administration added the condition to a list of several potential adverse events of particular interest. A few cases reported in people without detectable evidence of coronavirus infection prompted researchers at the CDC and elsewhere to conduct the new analysiswhich was published Tuesday in The Lancet Child & Adolescent Health.

The possibility that the vaccines may induce the condition in some way is only theoretical, and the analysis found no evidence that it did, said co-author Dr. Buddy Creech, a specialist in pediatric infectious diseases from Vanderbilt University, who is leading a study of Moderna shots in children.

“We do not know what the exact contribution of the vaccine to these diseases is,” Creech said. “Vaccine alone in the absence of a prior infection does not appear to be a significant trigger.”

The analysis involved surveillance data for the first nine months of COVID-19 vaccination in the United States, from December 2020 to August 2021. During that time, the FDA approved Pfizer’s COVID-19 shots for 16 years and up; extended it in May to ages 12 to 15; and approved Moderna and Johnson & Johnson recordings for ages 18 and up.

More than 21 million people aged 12 to 20 received at least one vaccine dose during that time period. Twenty-one of them developed the inflammatory condition afterwards. Everyone had received Pfizer shots, the analysis showed. Fifteen of the 21 had laboratory evidence of a previous COVID-19 infection that could have triggered the condition.

The remaining six had no evidence of a previous infection, but the researchers said they could not conclusively conclude that they had never had COVID-19 or another infection that could have led to the inflammatory condition. Children with COVID-19 often have no symptoms and many are never tested.

The results suggest that the inflammatory condition may occur after vaccination in 1 in 1 million children who have had COVID-19 and in 1 in 3 million who have no detectable evidence of previous COVID-19 infection.

Most children who had COVID-19 do not develop the post-infectious disease, but it is estimated to occur at a significantly higher rate than both of these numbers after vaccination. In April to June 2020, the frequency was 200 cases per million in unvaccinated infected individuals aged 12-20 years in the United States

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“Their results are generally quite reassuring,” wrote Dr. Mary Beth Son of Boston Children’s Hospital in a commentary accompanying the study.

Dr. Adam Ratner, a pediatrician-scientist at New York University Langone Health, said the results show that the chances are “super rare” for the shots to elicit an immune response that could lead to the inflammatory condition. In contrast, there is strong evidence that vaccination protects children from getting COVID-19 as well as the condition, Ratner said.

By Associated Press Medical Writer Lindsey Tanner

• • •

How to get tested

Tampa Bay: The Times can help you find free public COVID-19 test sites in Citrus, Hernando, Hillsborough, Manatee, Pasco, Pinellas, Polk, and Sarasota counties.

Florida: The National Board of Health has one website showing test sites in the state. Some information may be out of date.

USA: Department of Health and Human Services has one website which can help you find a test site.

• • •

How to get vaccinated

The COVID-19 vaccine for 5 years and up and booster shots for qualified recipients are administered at doctors’ offices, clinics, pharmacies, grocery stores and public vaccination sites. Many allow you to book appointments online. To find a site near you:

Find a website: Visit to find vaccination pages in your zip code.

More help: Call the National COVID-19 Vaccination Assistance Hotline.

Telephone: 800-232-0233. Help is available in English, Spanish and other languages.

TTY: 888-720-7489

Disability information and access line: Call 888-677-1199 or send an email to [email protected]

• • •

OMICRON VARIANT: Omicron changed what we know about COVID. Here’s the latest on how the infectious COVID-19 variant affects masks, vaccines, boosters and quarantine.

CHILDREN AND VACCINES: Do you have questions about vaccinating your child? Here are some answers.

BOOSTER SHOTS: Are you in doubt about which COVID booster you should have? This guide will help.

BOOSTER QUESTION: Are there any side effects? Why do I need it? Here are the answers to your questions.

PROTECTION OF SENIORS: This is how seniors can be safe from the virus.

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