High survival with lung transplant for COVID-19-associated ARDS – Consumer Health News
High survival with lung transplant for COVID-19-associated ARDS – Consumer Health News

High survival with lung transplant for COVID-19-associated ARDS – Consumer Health News

MONDAY, FEBRUARY 14, 2022 (HealthDay News) – Lung transplantation is successful for patients with COVID-19-associated acute respiratory distress syndrome (ARDS), with high survival, according to a study published online January 27 in Journal of the American Medical Association.

Chitaru Kurihara, MD, of Northwestern University in Chicago, and colleagues conducted a retrospective case series of 102 patients who underwent a lung transplant between January 21, 2020 and September 30, 2021, including 30 patients with COVID-19-associated ARDS.

The researchers found that the median lung allocation score was 85.8 versus 46.7 for lung transplant recipients with versus those without COVID-19; median time on the lung transplant waiting list was 11.5 versus 15 days, and 56.7 and 1.4 percent, respectively, used preoperative venovenous extracorporeal membrane oxygenation (ECMO). Patients with COVID-19-associated ARDS received transfusion of median 6.5 units of packed red blood cells during transplantation versus none for those without COVID-19; intraoperative venous arterial ECMO was used by 96.7 and 62.5 percent, respectively, and the mean surgery time was 8.5 versus 7.4 hours, respectively. The incidence of primary graft dysfunction within 72 hours was 70 versus 20.8 percent postoperatively for the COVID-19 cohort versus those without COVID-19; the median time to receive invasive mechanical ventilation was 6.5 versus 2.0 days, and 13.3 and 5.5 percent, respectively, needed permanent hemodialysis. Antibody-mediated rejection was detected by none of those with COVID-19-associated ARDS versus 12.5 percent of those without COVID-19. At follow-up, all COVID-19-associated ARDS lung transplant recipients were alive, compared with 83 percent in the non-COVID-19 cohort.

“Because of the inherent uncertainty in the prognosis, each patient’s progress must be determined longitudinally over time,” the authors write.

Abstract / full text

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