Incidence of COVID-19, multisystem inflammatory syndrome admissions in children
Incidence of COVID-19, multisystem inflammatory syndrome admissions in children

Incidence of COVID-19, multisystem inflammatory syndrome admissions in children

For every 1 COVID-19 hospitalization among children between the ages of 5 and 11, there was 1 hospitalization for multisystem inflammatory syndrome in children (MIS-C) during the winter of 2020 to 2021, according to a research letter published in JAMA Pediatrics.

Researchers performed a cross-sectional study to compare the severity and frequency of admissions due to COVID-19 infection plus MIS-C with those due to influenza and respiratory syncytial virus (RSV) infection.

Admission data from 1333 local hospitals in 11 U.S. states were obtained from to identify children diagnosed with COVID-19 infection, fluand RSV in the winter of 2020 to 2021. A total of 46 complications were examined, spanning the cardiovascular, respiratory, neurological, hematological, renal, gastrointestinal, and musculoskeletal systems.

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Data from 2269 children were included in the final analysis. The mean patient age was 7.6 (SD, 2.0) years, and 44% were girls. In terms of patient demographics, 2.2% were Asian or Pacific Islanders, 11.7% were black, 23.8% were Hispanic, 57.5% were non-Hispanic whites, and 4.8% were identified as others.

For each COVID-19 admission, there was a corresponding MIS-C admission, and combined admissions for both conditions occurred at a rate of 10.8 per day. 100,000 children. Although hospital admissions due to influenza and RSV in the same period had decreased significantly, the number of admissions among children with influenza and RSV in 2017 was 17.0 and 6.2 per year, respectively. 100,000.

The researchers found that the rates for cardiovascular (29.8%; 95% CI, 25.2-34.4; P = 0.001), haematological (55.4%; 95% CI, 50.4-60.4; P = 0.001), kidney (21.9%; 95% CI, 17.7-26.1; P = 0.001) and gastrointestinal (47.2%; 95% CI, 42.2-52.3; P = .001) complications were significantly increased among children with MIS-C. Children with RSV were found to have a significantly increased incidence of respiratory complications (75.8%; 95% CI, 71.6-79.9; P = .001). In addition, significantly increased incidences of neurological and musculoskeletal complications were observed among children with COVID-19 infection without MIS (9.6%; 95% CI, 6.5-12.8; P = .03) and those with influenza virus infection (9.5%; 95% CI, 7.8-11.2; P = .001).

The severity of MIS-C was significantly increased among those who were Asian or Pacific Islanders, blacks, Hispanics, and those who identified as others. Of these children with MIS, the total length of hospitalization was significantly increased compared to those who were not Hispanic White (1647 days versus 867 days; P = .047).

This study may have underestimated the national frequency and severity of MIS-C as the percentage of children enrolled who were Asian or Pacific Islanders,

Black, Hispanic, and other races / ethnicities were 39.4% compared to 50.2% for all U.S. states.

According to researchers, “[these] findings suggest that MIS-C may not be as rare from a COVID-19 sequelae as previously thought. “They concluded,”[this] study can provide important data points for public health planning efforts, including racial and ethnic minority group outreach to help [decrease] the disease burden of both COVID-19 [complicated by MIS-C] and influenza. “

Disclosure: A research author stated affiliation with biotech, pharmaceutical and / or unit companies. Please see the original reference for a complete list of information.


Encinosa W, Figueroa J, Elias Y. Severity of admissions from SARS-CoV-2 vs influenza and respiratory syncytial virus infection in children aged 5 to 11 years in 11 US states. JAMA Pediatrician. Published online February 21, 2022. doi: 10.1001 / jamapediatrics.2021.6566

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