April 22, 2022
1 min read
Source / Information
Edding S. et al. Poster 5. Presented at: National Kidney Foundation Spring Clinical Meetings; 5.-10. April 2022; Boston.
Information: Edding does not report any relevant financial information.
BOSTON – Intubated patients with COVID-19 pneumonia who develop AKI in the hospital are at risk of developing chronic kidney disease, according to a speaker at the National Kidney Foundation Spring Clinical Meetings.
“We already had an idea that intubated COVID-19 pneumonia patients were at risk of developing AKI, and we knew that these patients were not doing well in the acute situation.” Sherida EddingMD, from Lincoln Medical and Mental Health Center in New York, Healio said. “But we had patients who survived, and we were excited about whether this would put a strain on their kidneys. Will this episode of AKI put them at risk for developing CKD? There was not much longitudinal data available.”
In a retrospective case-control study, researchers evaluated data on 56 patients with COVID-19 pneumonia and 69 patients with bacterial pneumonia. All 125 patients developed AKI during hospitalization and were discharged alive between January 1, 2020 and December 30, 2020.
Using logistic regression analysis, the researchers identified the odds ratio for CKD on day 90 after a patient’s first AKI episode. In addition, researchers used Cox proportional hazard ratios to measure the risk of CKD on day 90.
Analyzes revealed that the hemodialysis rate was higher among patients with COVID-19 pneumonia (20%) than those with bacterial pneumonia (7%). Consequently, those with COVID-19 pneumonia were more likely to require dialysis after discharge (18%) than those with bacterial pneumonia (3%).
Researchers found that patients with COVID-19-associated AKI had a 148% increased risk of developing CKD after AKI compared with patients with bacterial pneumonia.
“Our study shows that critically ill, mechanically intubated COVID pneumonia patients had a higher probability and risk of progression from AKI to CKD, ”Edding told Healio. As clinicians, this translates to closely monitoring our patients’ kidney function when we see them on an outpatient basis – on top of evaluating for other long-term COVID symptoms. This also shows that there may be additional pathophysiology of the COVID virus to the kidneys that makes them more sick. “