PLWH, aging and the effects of COVID-19 results
PLWH, aging and the effects of COVID-19 results

PLWH, aging and the effects of COVID-19 results

PLWH may have an accelerated aging process and this may affect the severity of COVID-19. Investigators from the University of South Carolina and the University of Washington wanted to see if this population was more likely to have a more severe case of COVID-19. Adverse outcomes were identified as hospitalization and mortality.

Based on the results of their study, they wrote, Impact of Aging in HIV on COVID-19 Outcomes via a Matched Study, a poster presented at 2022 Annual Conference on Retrovirus and Opportunistic Infection (CROI).

The investigators used the National COVID Cohort Collaborative (N3C) to identify COVID-19 patients. From the N3C, 2,422,864 adults diagnosed with COVID-19 were identified between January 1, 2020 and October 18, 2021. Within this cohort, 15,188 were PLWH.

Investigators matched PLWH and non-PLWH COVID-19 based on age, gender, race, and ethnicity.

“PLWH had higher odds for both negative COVID-19 outcomes [hospitalization: OR: 1.50, 95%CI: (1.42, 1.58); death: OR: 1.48, 95%CI: (1.29, 1.69)]”Specifically, the investigators wrote. PLWH with a recent CD4 count <200 had worse COVID-19 clinical outcomes, they reported.

Of PLWH, 6,219 (40.9%) had CD4 counts within 180 days prior to diagnosis of COVID-19, among whom 872 (14.0%) had the most recent CD4 count <200 cells / mm3, while 5,347 (86, 0%) had CD4 count ≥200 cells / mm3.

“Compared to non-PLWH, PLWH had significantly high COVID-19-related mortality and hospitalization,” the investigators concluded.

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