The booster effect decreases after 4 months, still protects against severe COVID-19
The booster effect decreases after 4 months, still protects against severe COVID-19

The booster effect decreases after 4 months, still protects against severe COVID-19

Only as a primary Vaccine against covid-19 the series decreases with time booster The doses also decrease in effectiveness. This week, the US Centers for Disease Control and Prevention (CDC) reported that although a Pfizer-BioNTech or Moderna booster dose increases the effectiveness of the vaccine, their protection decreases even faster than the first vaccination.

In their Weekly report on morbidity and mortality (MMRR), the CDC published a study that found that the effectiveness of booster doses decreases significantly after 4 months.

Performed during the period when the highly transmissible Omicron was the dominant COVID-19 variant, the study showed that in the first 2 months after a third booster dose, the recipients had a 91% reduced risk of hospitalization. In the fourth month after boosting, vaccine protection against hospitalization had dropped to 78%.

The test-negative case-control study used data from 8 VISION Network sites that analyzed the vaccine’s efficacy against COVID-19 emergency room / emergency care (ED / UC) visits and hospitalizations among adults 18 years and older. The VISION Network data included 241,204 ED / UC meetings and 93,408 hospital admissions in 10 U.S. states from August 26, 2021 to January 22, 2022, representing several times after receiving a second or third dose of vaccine under the dominance of both Delta and Omicron. variants.

During both the Delta and Omicron periods, antibody levels were higher after a third dose than after a second, but vaccine protection decreased more rapidly during the Omicron period. Vaccine efficacy for participants receiving 2 or 3 doses was lower during the Omicron period than during the Delta period.

Under Omicron, vaccine efficacy against ED / UC visits was 87% during the first 2 months after a booster dose and decreased to 66% 4-5 months after vaccination. Protection against hospitalizations was 91% in the first 2 months after boosting, decreasing to 78% 4 or more months after receiving the third dose.

Falling vaccines have become a major concern, especially as Omicron continues to cause breakthrough infections. However, investigators found that boosters raise enough antibodies to provide lasting protection against serious COVID-19 disease, hospitalization and death. The authors of the study wrote: “All eligible individuals should stay up to date with recommended COVID-19 vaccinations to best protect against COVID-19-associated hospitalizations and ED / UC visits.”

The CDC is currently recommending all persons 12 and older receive an mRNA booster vaccine:

  • 6 months after initial vaccination for Moderna (mRNA-1273) recipients
  • 5 months after initial vaccination for Pfizer-BioNTech (BNT162b)
  • 2 months after initial vaccination for Janssen (Johnson & Johnson; Ad26.COV2.S) recipients

Both mRNA vaccines are currently preferred over the Janssen vaccineas boosters and as a primary series, although vaccination with Janssen is recommended if no other COVID-19 vaccine is available

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